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Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme influencing the metabolism of fluoropyrimidines. The relevance of MTHFR polymorphisms with the clinical response to fluoropyrimidine-based chemotherapy has been explored, but the results remain controversial. Thus, a meta-analysis was...

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Detalles Bibliográficos
Autores principales:	Zhong, Lei, He, Xia, Zhang, Yuan, Chuan, Jun-Lan, Chen, Min, Zhu, Shao-Min, Peng, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Meta-Analysis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101282/ https://www.ncbi.nlm.nih.gov/pubmed/30131855 http://dx.doi.org/10.18632/oncotarget.24933

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