Cargando…

Prior administration of vitamin K(2) improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization

Zoledronic acid (ZA) exerts complex influence on bone by suppressing bone resorption, mostly due to the direct osteoclasts inhibition and uncertain influence on osteoblasts. Vitamin K(2) (VK(2), Menaquinone-4) as an anabolic agent stimulates bone formation via anti-apoptosis in osteoblasts and mild...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Bin, Zhao, Wenqian, Wang, Yiqiang, Zhao, Zhao, Zhao, Changfeng, Wang, Shue, Gao, Chunzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101397/
https://www.ncbi.nlm.nih.gov/pubmed/30125322
http://dx.doi.org/10.1371/journal.pone.0202269