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Prior administration of vitamin K(2) improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization
Zoledronic acid (ZA) exerts complex influence on bone by suppressing bone resorption, mostly due to the direct osteoclasts inhibition and uncertain influence on osteoblasts. Vitamin K(2) (VK(2), Menaquinone-4) as an anabolic agent stimulates bone formation via anti-apoptosis in osteoblasts and mild...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101397/ https://www.ncbi.nlm.nih.gov/pubmed/30125322 http://dx.doi.org/10.1371/journal.pone.0202269 |