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Prion acute synaptotoxicity is largely driven by protease-resistant PrP(Sc) species
Although misfolding of normal prion protein (PrP(C)) into abnormal conformers (PrP(Sc)) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology paradigm, herein we report that at least modestly p...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101418/ https://www.ncbi.nlm.nih.gov/pubmed/30089152 http://dx.doi.org/10.1371/journal.ppat.1007214 |