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Prion acute synaptotoxicity is largely driven by protease-resistant PrP(Sc) species

Although misfolding of normal prion protein (PrP(C)) into abnormal conformers (PrP(Sc)) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology paradigm, herein we report that at least modestly p...

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Detalles Bibliográficos
Autores principales:	Foliaki, Simote Totauhelotu, Lewis, Victoria, Finkelstein, David Isaac, Lawson, Victoria, Coleman, Harold Arthur, Senesi, Matteo, Islam, Abu Mohammed Taufiqual, Chen, Feng, Sarros, Shannon, Roberts, Blaine, Adlard, Paul Anthony, Collins, Steven John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101418/ https://www.ncbi.nlm.nih.gov/pubmed/30089152 http://dx.doi.org/10.1371/journal.ppat.1007214

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