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Potato consumption and risk of pancreatic cancer in the HELGA cohort

Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospectiv...

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Autores principales: Åsli, Lene A., Braaten, Tonje, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Nilsson, Lena Maria, Renström, Frida, Lund, Eiliv, Skeie, Guri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101424/
https://www.ncbi.nlm.nih.gov/pubmed/29845900
http://dx.doi.org/10.1017/S0007114518000788
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author Åsli, Lene A.
Braaten, Tonje
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Nilsson, Lena Maria
Renström, Frida
Lund, Eiliv
Skeie, Guri
author_facet Åsli, Lene A.
Braaten, Tonje
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Nilsson, Lena Maria
Renström, Frida
Lund, Eiliv
Skeie, Guri
author_sort Åsli, Lene A.
collection PubMed
description Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ’s), lifestyle and health was collected by means of a questionnaire, and 221 pancreatic cancer cases were identified through cancer registries. The mean follow-up time was 11·4 (95 % CI 0·3, 16·9) years. High consumption of potatoes showed a non-significantly higher risk of pancreatic cancer in the adjusted model (hazard ratio (HR) 1·44; 95 % CI 0·93, 2·22, P (for trend) 0·030) when comparing the highest v. the lowest quartile of potato consumption. In the sex-specific analyses, significant associations were found for females (HR 2·00; 95 % CI 1·07, 3·72, P (for trend) 0·020), but not for males (HR 1·01; 95 % CI 0·56, 1·84, P (for trend) 0·34). In addition, we explored the associations by spline regression, and the absence of dose–response effects was confirmed. In this study, high potato consumption was not consistently associated with a higher risk of pancreatic cancer. Further studies with larger populations are needed to explore the possible sex difference.
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spelling pubmed-61014242018-08-23 Potato consumption and risk of pancreatic cancer in the HELGA cohort Åsli, Lene A. Braaten, Tonje Olsen, Anja Tjønneland, Anne Overvad, Kim Nilsson, Lena Maria Renström, Frida Lund, Eiliv Skeie, Guri Br J Nutr Review-Systematic with Meta-Analysis Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ’s), lifestyle and health was collected by means of a questionnaire, and 221 pancreatic cancer cases were identified through cancer registries. The mean follow-up time was 11·4 (95 % CI 0·3, 16·9) years. High consumption of potatoes showed a non-significantly higher risk of pancreatic cancer in the adjusted model (hazard ratio (HR) 1·44; 95 % CI 0·93, 2·22, P (for trend) 0·030) when comparing the highest v. the lowest quartile of potato consumption. In the sex-specific analyses, significant associations were found for females (HR 2·00; 95 % CI 1·07, 3·72, P (for trend) 0·020), but not for males (HR 1·01; 95 % CI 0·56, 1·84, P (for trend) 0·34). In addition, we explored the associations by spline regression, and the absence of dose–response effects was confirmed. In this study, high potato consumption was not consistently associated with a higher risk of pancreatic cancer. Further studies with larger populations are needed to explore the possible sex difference. Cambridge University Press 2018-06-28 /pmc/articles/PMC6101424/ /pubmed/29845900 http://dx.doi.org/10.1017/S0007114518000788 Text en © The Authors 2018
spellingShingle Review-Systematic with Meta-Analysis
Åsli, Lene A.
Braaten, Tonje
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Nilsson, Lena Maria
Renström, Frida
Lund, Eiliv
Skeie, Guri
Potato consumption and risk of pancreatic cancer in the HELGA cohort
title Potato consumption and risk of pancreatic cancer in the HELGA cohort
title_full Potato consumption and risk of pancreatic cancer in the HELGA cohort
title_fullStr Potato consumption and risk of pancreatic cancer in the HELGA cohort
title_full_unstemmed Potato consumption and risk of pancreatic cancer in the HELGA cohort
title_short Potato consumption and risk of pancreatic cancer in the HELGA cohort
title_sort potato consumption and risk of pancreatic cancer in the helga cohort
topic Review-Systematic with Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101424/
https://www.ncbi.nlm.nih.gov/pubmed/29845900
http://dx.doi.org/10.1017/S0007114518000788
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