Intrinsically disordered domain of tumor suppressor p53 facilitates target search by ultrafast transfer between different DNA strands

Intersegmental transfer (IST) is an important strategy in the target search used by sequence-specific DNA-binding proteins (DBPs), enabling DBPs to search for targets between multiple DNA strands without dissociation. We examined the IST of the tumor suppressor p53 using ensemble stopped-flow and si...

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Detalles Bibliográficos
Autores principales: Itoh, Yuji, Murata, Agato, Takahashi, Satoshi, Kamagata, Kiyoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101536/
https://www.ncbi.nlm.nih.gov/pubmed/29986056
http://dx.doi.org/10.1093/nar/gky586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101536/
https://www.ncbi.nlm.nih.gov/pubmed/29986056
http://dx.doi.org/10.1093/nar/gky586

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