Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates

DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant DNA methylation patterns have been described in cancer. However, only a small fraction of differential methylation events target genes with a defined role in cancer, raising the question of how aberrant DNA methy...

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Detalles Bibliográficos
Autores principales: Dmitrijeva, Marija, Ossowski, Stephan, Serrano, Luis, Schaefer, Martin H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101545/
https://www.ncbi.nlm.nih.gov/pubmed/29893918
http://dx.doi.org/10.1093/nar/gky498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101545/
https://www.ncbi.nlm.nih.gov/pubmed/29893918
http://dx.doi.org/10.1093/nar/gky498

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