Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex

Small-molecule compounds that target mismatched base pairs in DNA offer a novel prospective for cancer diagnosis and therapy. The potent anticancer antibiotic echinomycin functions by intercalating into DNA at CpG sites. Surprisingly, we found that the drug strongly prefers to bind to consecutive Cp...

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Detalles Bibliográficos
Autores principales: Wu, Pei-Ching, Tzeng, Shu-Ling, Chang, Chung-ke, Kao, Ya-Fen, Waring, Michael J, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101601/
https://www.ncbi.nlm.nih.gov/pubmed/29741655
http://dx.doi.org/10.1093/nar/gky345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101601/
https://www.ncbi.nlm.nih.gov/pubmed/29741655
http://dx.doi.org/10.1093/nar/gky345

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