Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we show that HIV-1 CA can bind multiple Nups, and that both natural and manipulated variation in Nup levels impacts HIV-1 i...

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Detalles Bibliográficos
Autores principales: Kane, Melissa, Rebensburg, Stephanie V, Takata, Matthew A, Zang, Trinity M, Yamashita, Masahiro, Kvaratskhelia, Mamuka, Bieniasz, Paul D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101944/
https://www.ncbi.nlm.nih.gov/pubmed/30084827
http://dx.doi.org/10.7554/eLife.35738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101944/
https://www.ncbi.nlm.nih.gov/pubmed/30084827
http://dx.doi.org/10.7554/eLife.35738

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