Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability. Using CD analysis, solid-state NMR spectroscopy, and tra...

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Detalles Bibliográficos
Autores principales: Townsend, David, Hughes, Eleri, Akien, Geoffrey, Stewart, Katie L., Radford, Sheena E., Rochester, David, Middleton, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102129/
https://www.ncbi.nlm.nih.gov/pubmed/29853648
http://dx.doi.org/10.1074/jbc.RA118.002038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102129/
https://www.ncbi.nlm.nih.gov/pubmed/29853648
http://dx.doi.org/10.1074/jbc.RA118.002038

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