Disulfide-crosslink scanning reveals prion–induced conformational changes and prion strain–specific structures of the pathological prion protein PrP(Sc)

Prions are composed solely of the pathological isoform (PrP(Sc)) of the normal cellular prion protein (PrP(C)). Identification of different PrP(Sc) structures is crucially important for understanding prion biology because the pathogenic properties of prions are hypothesized to be encoded in the stru...

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Detalles Bibliográficos
Autores principales: Taguchi, Yuzuru, Lu, Li, Marrero-Winkens, Cristobal, Otaki, Hiroki, Nishida, Noriyuki, Schatzl, Hermann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102138/
https://www.ncbi.nlm.nih.gov/pubmed/29934306
http://dx.doi.org/10.1074/jbc.RA117.001633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102138/
https://www.ncbi.nlm.nih.gov/pubmed/29934306
http://dx.doi.org/10.1074/jbc.RA117.001633

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