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SERCA is critical to control the Bowditch effect in the heart

The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase. The healthy and failing human heart both show positive or negative staircase, respectively, but the causes of these distinct c...

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Detalles Bibliográficos
Autores principales: Balcazar, Darío, Regge, Victoria, Santalla, Manuela, Meyer, Heiko, Paululat, Achim, Mattiazzi, Alicia, Ferrero, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102201/
https://www.ncbi.nlm.nih.gov/pubmed/30127403
http://dx.doi.org/10.1038/s41598-018-30638-9