CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson’s Disease

Parkinson’s disease (PD) is a common, progressive neurodegenerative disorder characterized by classical motor dysfunction and is associated with α-synuclein-immunopositive pathology and the loss of dopaminergic neurons in the substantia nigra (SN). Several missense mutations in the α-synuclein gene...

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Detalles Bibliográficos
Autores principales: Zhu, Xiang-Xing, Zhong, Yi-Zhi, Ge, Yao-Wen, Lu, Ke-Huan, Lu, Sheng-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102220/
https://www.ncbi.nlm.nih.gov/pubmed/30127453
http://dx.doi.org/10.1038/s41598-018-30436-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102220/
https://www.ncbi.nlm.nih.gov/pubmed/30127453
http://dx.doi.org/10.1038/s41598-018-30436-3

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