DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile

Docosahexaenoic acid (DHA) and their CYP-derived metabolites, epoxydocosapentaenoic acids (EDPs), are important fatty acids obtained from dietary sources. While it is known that they have significant biological effects, which can differ between cell type and disease state, our understanding of how t...

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Detalles Bibliográficos
Autores principales: Endo, Tomoko, Samokhvalov, Victor, Darwesh, Ahmed M., Khey, Kevin M. W., El-Sherbeni, Ahmed A., El-Kadi, Ayman O. S., Machida, Takuji, Hirafuji, Masahiko, Seubert, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102239/
https://www.ncbi.nlm.nih.gov/pubmed/30131878
http://dx.doi.org/10.1038/s41420-018-0090-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102239/
https://www.ncbi.nlm.nih.gov/pubmed/30131878
http://dx.doi.org/10.1038/s41420-018-0090-1

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