The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation

FAT10 is a ubiquitin-like modifier that directly targets proteins for proteasomal degradation. Here, we report the high-resolution structures of the two individual ubiquitin-like domains (UBD) of FAT10 that are joined by a flexible linker. While the UBDs of FAT10 show the typical ubiquitin-fold, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Aichem, Annette, Anders, Samira, Catone, Nicola, Rößler, Philip, Stotz, Sophie, Berg, Andrej, Schwab, Ricarda, Scheuermann, Sophia, Bialas, Johanna, Schütz-Stoffregen, Mira C., Schmidtke, Gunter, Peter, Christine, Groettrup, Marcus, Wiesner, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102260/
https://www.ncbi.nlm.nih.gov/pubmed/30127417
http://dx.doi.org/10.1038/s41467-018-05776-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102260/
https://www.ncbi.nlm.nih.gov/pubmed/30127417
http://dx.doi.org/10.1038/s41467-018-05776-3

Ejemplares similares