HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice

The kinase C-related kinase 2 (PRK2), which phosphorylates hepatitis C virus (HCV) RNA polymerase, is a proviral factor enhancing HCV replication. Here, we report on the in vivo anti-HCV efficacy of HA1077, which inhibits viral genome replication by targeting PRK2 and displays viral entry inhibitory...

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Detalles Bibliográficos
Autores principales: Lee, Seung-Hoon, Moon, Jae-Su, Pak, Bo-Yeong, Kim, Geon-Woo, Lee, Wooseong, Cho, Hee, Kim, SangKyu, Kim, Seong-Jun, Oh, Jong-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102265/
https://www.ncbi.nlm.nih.gov/pubmed/30127498
http://dx.doi.org/10.1038/s41598-018-30460-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102265/
https://www.ncbi.nlm.nih.gov/pubmed/30127498
http://dx.doi.org/10.1038/s41598-018-30460-3

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