Cargando…

HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice

The kinase C-related kinase 2 (PRK2), which phosphorylates hepatitis C virus (HCV) RNA polymerase, is a proviral factor enhancing HCV replication. Here, we report on the in vivo anti-HCV efficacy of HA1077, which inhibits viral genome replication by targeting PRK2 and displays viral entry inhibitory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seung-Hoon, Moon, Jae-Su, Pak, Bo-Yeong, Kim, Geon-Woo, Lee, Wooseong, Cho, Hee, Kim, SangKyu, Kim, Seong-Jun, Oh, Jong-Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102265/ https://www.ncbi.nlm.nih.gov/pubmed/30127498 http://dx.doi.org/10.1038/s41598-018-30460-3

Ejemplares similares

A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir
por: Fernandes Campos, Guilherme Rodrigues, et al.
Publicado: (2020)

Corrigendum: A novel substitution in NS5A enhances resistance of hepatitis C virus genotype 3 to daclatasvir
por: Fernandes Campos, Guilherme Rodrigues, et al.
Publicado: (2021)

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells
por: Abe, Hideyuki, et al.
Publicado: (2014)

Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.
por: Siomboing, X, et al.
Publicado: (2001)

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease
por: Li, Mei, et al.
Publicado: (2013)

The Discovery and Development of Daclatasvir: An Inhibitor of the Hepatitis C Virus NS5A Replication Complex
por: Meanwell, Nicholas A., et al.
Publicado: (2018)

Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions
por: Fujii, Hideki, et al.
Publicado: (2017)

Sofosbuvir and daclatasvir
por: Hessel, Marleen H. M., et al.
Publicado: (2016)

Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition
por: Schmidt, Julie A., et al.
Publicado: (2017)

Evaluation of Resistance-Associated Substitutions in NS5A Using Direct Sequence and Cycleave Method and Treatment Outcome with Daclatasvir and Asunaprevir for Chronic Hepatitis C Genotype 1
por: Ide, Tatsuya, et al.
Publicado: (2016)

Daclatasvir: potential role in hepatitis C
por: Lee, Choongho
Publicado: (2013)

NS5A Sequence Heterogeneity and Mechanisms of Daclatasvir Resistance in Hepatitis C Virus Genotype 4 Infection
por: Zhou, Nannan, et al.
Publicado: (2016)

1077. Heart Transplantation as Salvage Treatment for Intractable Infective Endocarditis
por: Tattevin, Pierre, et al.
Publicado: (2018)

Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition
por: Nettles, James H., et al.
Publicado: (2014)

Efficacy and Safety of Daclatasvir and Asunaprevir in Patients with Hepatitis C Virus Genotype 1b Infection on Hemodialysis
por: Lee, Byung Seok, et al.
Publicado: (2019)

Synergistic inhibition of hepatitis C virus infection by a novel microtubule inhibitor in combination with daclatasvir
por: Zhang, Huijun, et al.
Publicado: (2022)

Complex Pattern of Resistance-Associated Substitutions of Hepatitis C Virus after Daclatasvir/Asunaprevir Treatment Failure
por: Itakura, Jun, et al.
Publicado: (2016)

P1077: HODGKIN LYMPHOMA IN PATIENTS WITH HIV: NATIONAL RETROSPECTIVE MULTICENTER STUDY
por: Chekalov, A., et al.
Publicado: (2022)

Studies of the symmetric binding mode of daclatasvir and analogs using a new homology model of HCV NS5A GT-4a
por: Saad, Kholoud A., et al.
Publicado: (2022)

Regulation of La/SSB-dependent viral gene expression by pre-tRNA 3′ trailer-derived tRNA fragments
por: Cho, Hee, et al.
Publicado: (2019)

1077. Reduce Anti-Microbial Use in Extracorporeal Membrane Oxygenation: Reduce AMMO Study
por: Shah, Aditya, et al.
Publicado: (2019)

Causes of Hand Tingling in Visual Display Terminal Workers
por: Oh, Sein, et al.
Publicado: (2013)

High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms
por: McPhee, Fiona, et al.
Publicado: (2015)

Daclatasvir: potential role in hepatitis C [Corrigendum]
Publicado: (2014)

Efficacy and Safety of Daclatasvir in Hepatitis C: An Overview
por: Gamal, Nesrine, et al.
Publicado: (2016)

A Review of Daclatasvir Drug–Drug Interactions
por: Garimella, Tushar, et al.
Publicado: (2016)

Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir
por: Ashraf, Taha, et al.
Publicado: (2017)

Synergistic Effects of Heat-Treated Green Tea Extract and Enzymatically-Modified Isoquercitrin in Preventing Obesity
por: Moon, Ye-jin, et al.
Publicado: (2023)

Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model
por: Roh, Jiyeon, et al.
Publicado: (2016)

Phenotypic expression of the p.Leu1077Pro CFTR mutation in Sicilian cystic fibrosis patients
por: Parisi, Giuseppe Fabio, et al.
Publicado: (2013)

Primary mucosal melanoma of the sinonasal tract: Report of 18 patients and analysis of 1077 patients in the literature
por: Khademi, Bijan, et al.
Publicado: (2015)

Efficacy and safety of daclatasvir plus asunaprevir for Korean patients with HCV genotype Ib infection: a retrospective multi-institutional study
por: Cho, Byeong Wook, et al.
Publicado: (2017)

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers
por: Cohen, Alexander A., et al.
Publicado: (2021)

1077. Understanding the Psychosocial Burden Associated with Hospitalization Among Adults Diagnosed with COVID-19 in the United States
por: Ansari, Wajeeha, et al.
Publicado: (2022)

Synergistic Inhibition of Tumor Necrosis Factor-Alpha-Stimulated Pro-Inflammatory Cytokine Expression in HaCaT Cells by a Combination of Rapamycin and Mycophenolic Acid
por: Kim, Min Young, et al.
Publicado: (2015)

Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety
por: Lee, Hye Won, et al.
Publicado: (2018)

Biological properties of influenza A virus mutants with amino acid substitutions in the HA2 glycoprotein of the HA1/HA2 interaction region
por: Jakubcová, L., et al.
Publicado: (2019)

Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection
por: Morishita, Naoki, et al.
Publicado: (2020)

Current Updates on COVID-19 Vaccines and Therapeutics: As of June 2022
por: Lee, Wooseong, et al.
Publicado: (2022)

Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity
por: Lee, Wooseong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hjdr2si2kk1f7q7d1cpdmqrn44