The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway

Tyrosine phosphorylation of Fas (TNFRSF6/CD95) in its death domain turns off Fas-mediated apoptosis, turns on the pro-survival signal, and has implications in different cancers types. We show here that Fas in its pro-survival state, phosphorylated at Y291 (pY291-Fas), functionally interacts with the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ta, Ngoc Ly, Chakrabandhu, Krittalak, Huault, Sébastien, Hueber, Anne-Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102278/
https://www.ncbi.nlm.nih.gov/pubmed/30127519
http://dx.doi.org/10.1038/s41598-018-30804-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102278/
https://www.ncbi.nlm.nih.gov/pubmed/30127519
http://dx.doi.org/10.1038/s41598-018-30804-z

Ejemplares similares