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The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway

Tyrosine phosphorylation of Fas (TNFRSF6/CD95) in its death domain turns off Fas-mediated apoptosis, turns on the pro-survival signal, and has implications in different cancers types. We show here that Fas in its pro-survival state, phosphorylated at Y291 (pY291-Fas), functionally interacts with the...

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Detalles Bibliográficos
Autores principales:	Ta, Ngoc Ly, Chakrabandhu, Krittalak, Huault, Sébastien, Hueber, Anne-Odile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102278/ https://www.ncbi.nlm.nih.gov/pubmed/30127519 http://dx.doi.org/10.1038/s41598-018-30804-z

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