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Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience

Designer receptors exclusively activated by designer drugs (DREADDs) are popular tools used to manipulate the activity of defined groups of neurons. Recent work has shown that DREADD effects in the brain are most likely not mediated by the proposed ligand clozapine-N-oxide (CNO) but its metabolite c...

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Detalles Bibliográficos
Autores principales: Ilg, Ann-Kathrin, Enkel, Thomas, Bartsch, Dusan, Bähner, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102325/
https://www.ncbi.nlm.nih.gov/pubmed/30154702
http://dx.doi.org/10.3389/fnbeh.2018.00173