Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures From DMD Patients

Oxidative stress and mitochondrial dysfunction play a crucial role in the pathophysiology of muscular dystrophies. We previously reported that the mitochondrial enzyme monoamine oxidase (MAO) is a relevant source of reactive oxygen species (ROS) not only in murine models of muscular dystrophy, in wh...

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Detalles Bibliográficos
Autores principales: Vitiello, Libero, Marabita, Manuela, Sorato, Elisa, Nogara, Leonardo, Forestan, Giada, Mouly, Vincent, Salviati, Leonardo, Acosta, Manuel, Blaauw, Bert, Canton, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102489/
https://www.ncbi.nlm.nih.gov/pubmed/30154729
http://dx.doi.org/10.3389/fphys.2018.01087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102489/
https://www.ncbi.nlm.nih.gov/pubmed/30154729
http://dx.doi.org/10.3389/fphys.2018.01087

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