Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder

GLYX-13, a NMDAR glycine-site partial agonist, was discovered as a promising antidepressant with rapidly acting effects but no ketamine-like side effects. However, the reported synthetic process route had deficiencies of low yield and the use of unfriendly reagents. Here, we report a scaled-up synth...

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Detalles Bibliográficos
Autores principales: Li, Wenchao, Liu, Jingjian, Fan, Minghua, Li, Zhongtang, Chen, Yin, Zhang, Guisen, Huang, Zhuo, Zhang, Liangren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102568/
https://www.ncbi.nlm.nih.gov/pubmed/29695090
http://dx.doi.org/10.3390/molecules23050996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102568/
https://www.ncbi.nlm.nih.gov/pubmed/29695090
http://dx.doi.org/10.3390/molecules23050996

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