Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors †

Targeting DNA damage and response (DDR) pathway has become an attractive approach in cancer therapy. The key mediators involved in this pathway are ataxia telangiectasia-mutated kinase (ATM) and ataxia telangiectasia-mutated, Rad3-related kinase (ATR). These kinases induce cell cycle arrest in respo...

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Detalles Bibliográficos
Autores principales: Shaik, Althaf, Bhakuni, Rashmi, Kirubakaran, Sivapriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102578/
https://www.ncbi.nlm.nih.gov/pubmed/29695073
http://dx.doi.org/10.3390/molecules23050992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102578/
https://www.ncbi.nlm.nih.gov/pubmed/29695073
http://dx.doi.org/10.3390/molecules23050992

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