ROS-mediated autophagy through the AMPK signaling pathway protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity

Oligomerization of human islet amyloid polypeptide (hIAPP) is toxic and contributes to progressive reduction of β cell mass in patients with type 2 diabetes mellitus. Autophagy is a highly conserved homeostatic mechanism in eukaryotes. Previous studies have confirmed that hIAPP can promote autophagy...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Guanghao, Zhu, Tiehong, Li, Xiaotong, Jin, Yujing, Zhou, Jing, Xiao, Jinfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102651/
https://www.ncbi.nlm.nih.gov/pubmed/30015901
http://dx.doi.org/10.3892/mmr.2018.9248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102651/
https://www.ncbi.nlm.nih.gov/pubmed/30015901
http://dx.doi.org/10.3892/mmr.2018.9248

Ejemplares similares