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ROS-mediated autophagy through the AMPK signaling pathway protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity

Oligomerization of human islet amyloid polypeptide (hIAPP) is toxic and contributes to progressive reduction of β cell mass in patients with type 2 diabetes mellitus. Autophagy is a highly conserved homeostatic mechanism in eukaryotes. Previous studies have confirmed that hIAPP can promote autophagy...

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Detalles Bibliográficos
Autores principales:	Xia, Guanghao, Zhu, Tiehong, Li, Xiaotong, Jin, Yujing, Zhou, Jing, Xiao, Jinfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102651/ https://www.ncbi.nlm.nih.gov/pubmed/30015901 http://dx.doi.org/10.3892/mmr.2018.9248

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