Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection

BACKGROUND: Reproducibility of hits from independent CRISPR or siRNA screens is poor. This is partly due to data normalization primarily addressing technical variability within independent screens, and not the technical differences between them. RESULTS: We present “rscreenorm”, a method that standa...

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Detalles Bibliográficos
Autores principales: Bachas, Costa, Hodzic, Jasmina, van der Mijn, Johannes C., Stoepker, Chantal, Verheul, Henk M. W., Wolthuis, Rob M. F., Felley-Bosco, Emanuela, van Wieringen, Wessel N., van Beusechem, Victor W., Brakenhoff, Ruud H., de Menezes, Renée X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102854/
https://www.ncbi.nlm.nih.gov/pubmed/30126372
http://dx.doi.org/10.1186/s12859-018-2306-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102854/
https://www.ncbi.nlm.nih.gov/pubmed/30126372
http://dx.doi.org/10.1186/s12859-018-2306-z

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