Cargando…

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

BACKGROUND: T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Li, Sun, Wen J., Jia, Ai J., Qiu, Lu L., Xiao, Bing, Mu, Lin, Li, Jian M., Zhang, Xiu F., Wei, Yan, Peng, Cong, Zhang, Dong S., Xiang, Xu D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102869/ https://www.ncbi.nlm.nih.gov/pubmed/30150897 http://dx.doi.org/10.1186/s12950-018-0191-x

Ejemplares similares

MBD2 mediates Th17 cell differentiation by regulating MINK1 in Th17-dominant asthma
por: Chen, Zhifeng, et al.
Publicado: (2022)

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
por: Jia, Aijun, et al.
Publicado: (2017)

Androgen Plays a Potential Novel Hormonal Therapeutic Role in Th17 Cells Predominant Neutrophilic Severe Asthma by Attenuating BECs Regulated Th17 Cells Differentiation via MBD2 Expression
por: Wasti, Binaya, et al.
Publicado: (2022)

miR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma
por: Duan, Wentao, et al.
Publicado: (2023)

MBD2 as a Potential Novel Biomarker for Identifying Severe Asthma With Different Endotypes
por: Chen, Zhifeng, et al.
Publicado: (2021)

The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation
por: Zhou, Jing, et al.
Publicado: (2021)

Effect of IL-7 on Th17 cell responses in a mouse model of neutrophilic asthma
por: Zhang, Xiaobo, et al.
Publicado: (2020)

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
por: Cook, Peter C., et al.
Publicado: (2015)

Role of Th17-cell related cytokines in geriatric asthma
por: Quan-san, Zhang, et al.
Publicado: (2018)

MBD2 and MBD3: elusive functions and mechanisms
por: Menafra, Roberta, et al.
Publicado: (2014)

Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma
por: Wei, Qing, et al.
Publicado: (2021)

Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma
por: Zhang, Fang, et al.
Publicado: (2017)

DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells
por: Hainer, Sarah J, et al.
Publicado: (2016)

Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma
por: Wasti, Binaya, et al.
Publicado: (2021)

Impact of cinacalcet introduction on MBD management: the MBD-5D study in Japan
por: Fukuma, Shingo, et al.
Publicado: (2013)

hMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma
por: Hong, Gyong Hwa, et al.
Publicado: (2017)

Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17
por: Harding, Jeffrey N., et al.
Publicado: (2021)

The Human Proteins MBD5 and MBD6 Associate with Heterochromatin but They Do Not Bind Methylated DNA
por: Laget, Sophie, et al.
Publicado: (2010)

Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma
por: Luo, Weihang, et al.
Publicado: (2022)

Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes
por: Fang, Shu-Bin, et al.
Publicado: (2018)

Prevention and Treatment of CKD-MBD
por: Cozzolino, Mario
Publicado: (2013)

Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice
por: Wei, Chaochao, et al.
Publicado: (2021)

Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?
por: Yang, Xu, et al.
Publicado: (2016)

Comparison of the roles of house dust mite allergens, ovalbumin and lipopolysaccharides in the sensitization of mice to establish a model of severe neutrophilic asthma
por: Jia, Aijun, et al.
Publicado: (2017)

The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation
por: Minns, Danielle, et al.
Publicado: (2021)

A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells
por: Bader, S A, et al.
Publicado: (2007)

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer
por: Tsuboyama, Natsumi, et al.
Publicado: (2022)

Increased Proportion of Dual-Positive Th2–Th17 Cells Promotes a More Severe Subtype of Asthma
por: Sun, Wenjin, et al.
Publicado: (2021)

Th17/Treg homeostasis, but not Th1/Th2 homeostasis, is implicated in exacerbation of human bronchial asthma
por: Zou, Xiao-ling, et al.
Publicado: (2018)

MBD2 facilitates tumor metastasis by mitigating DDB2 expression
por: Zhang, Lei, et al.
Publicado: (2023)

Acupuncture Attenuated Inflammation and Inhibited Th17 and Treg Activity in Experimental Asthma
por: Wei, Ying, et al.
Publicado: (2015)

MBD3 inhibits formation of liver cancer stem cells
por: Li, Ruizhi, et al.
Publicado: (2016)

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
por: Übel, Caroline, et al.
Publicado: (2014)

NOD2 Signaling Circuitry during Allergen Sensitization Does Not Worsen Experimental Neutrophilic Asthma but Promotes a Th2/Th17 Profile in Asthma Patients but Not Healthy Subjects
por: Bouté, Mélodie, et al.
Publicado: (2022)

Bronchial epithelial cells of young and old mice directly regulate the differentiation of Th2 and Th17
por: Liu, Da, et al.
Publicado: (2019)

CKD-MBD after kidney transplantation
por: Wesseling-Perry, Katherine, et al.
Publicado: (2011)

A Japanese approach for CKD-MBD
por: Yokoyama, Keitaro, et al.
Publicado: (2013)

The Role of Vitamin K in CKD-MBD
por: Fusaro, Maria, et al.
Publicado: (2022)

CKD-MBD diagnosis: biochemical abnormalities
por: Lucca, Leandro Junior, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pe0lei67osa8ghuru88dts5eou