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Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Alterations in excitation–contraction coupling and elevated intracellular sodium (Na(i)) are hallmarks of pathological cardiac remodelling that underline contractile dysfunction. In addition, changes in cardiac metabolism are observed in cardiac hypertrophy and heart failure (HF) that lead to a mism...

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Detalles Bibliográficos
Autores principales: Aksentijevic, Dunja, O'Brien, Brett A., Eykyn, Thomas R., Shattock, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103460/
https://www.ncbi.nlm.nih.gov/pubmed/29970448
http://dx.doi.org/10.1042/BST20170508