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Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

Altered metabolism in cancer cells is critical for tumor growth. One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism. Cells require one-carbon units for nucleotide synthesis, methylation reactions, and for the generation of reducing cofactors. Therefore, the...

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Detalles Bibliográficos
Autores principales: Rosenzweig, Adam, Blenis, John, Gomes, Ana P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103474/
https://www.ncbi.nlm.nih.gov/pubmed/30159313
http://dx.doi.org/10.3389/fcell.2018.00090
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author Rosenzweig, Adam
Blenis, John
Gomes, Ana P.
author_facet Rosenzweig, Adam
Blenis, John
Gomes, Ana P.
author_sort Rosenzweig, Adam
collection PubMed
description Altered metabolism in cancer cells is critical for tumor growth. One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism. Cells require one-carbon units for nucleotide synthesis, methylation reactions, and for the generation of reducing cofactors. Therefore, the ability to rewire and fine-tune one-carbon metabolism is essential for the maintenance of cellular homeostasis. In this review, we describe how the major nutrient, energy, and redox sensors of the cell play a significant role in the regulation of flux through one-carbon metabolism to enable cell fate decisions. We will also discuss how dysregulated oncogenic signaling hijacks these regulatory mechanisms to support and sustain high rates of proliferation and cell survival essential for tumor growth.
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spelling pubmed-61034742018-08-29 Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? Rosenzweig, Adam Blenis, John Gomes, Ana P. Front Cell Dev Biol Cell and Developmental Biology Altered metabolism in cancer cells is critical for tumor growth. One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism. Cells require one-carbon units for nucleotide synthesis, methylation reactions, and for the generation of reducing cofactors. Therefore, the ability to rewire and fine-tune one-carbon metabolism is essential for the maintenance of cellular homeostasis. In this review, we describe how the major nutrient, energy, and redox sensors of the cell play a significant role in the regulation of flux through one-carbon metabolism to enable cell fate decisions. We will also discuss how dysregulated oncogenic signaling hijacks these regulatory mechanisms to support and sustain high rates of proliferation and cell survival essential for tumor growth. Frontiers Media S.A. 2018-08-15 /pmc/articles/PMC6103474/ /pubmed/30159313 http://dx.doi.org/10.3389/fcell.2018.00090 Text en Copyright © 2018 Rosenzweig, Blenis and Gomes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rosenzweig, Adam
Blenis, John
Gomes, Ana P.
Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title_full Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title_fullStr Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title_full_unstemmed Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title_short Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?
title_sort beyond the warburg effect: how do cancer cells regulate one-carbon metabolism?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103474/
https://www.ncbi.nlm.nih.gov/pubmed/30159313
http://dx.doi.org/10.3389/fcell.2018.00090
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