A continuous assay for monitoring the synthetic and proofreading activities of multiple aminoacyl-tRNA synthetases for high-throughput drug discovery

Aminoacyl-tRNA synthetases (aaRSs) catalyze the aminoacylation of tRNAs to produce the aminoacyl-tRNAs (aa-tRNAs) required by ribosomes for translation of the genetic message into proteins. To ensure the accuracy of tRNA aminoacylation, and consequently the fidelity of protein synthesis, some aaRSs...

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Detalles Bibliográficos
Autores principales: Grube, Christopher D., Roy, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper - Solicited
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103669/
https://www.ncbi.nlm.nih.gov/pubmed/29168435
http://dx.doi.org/10.1080/15476286.2017.1397262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103669/
https://www.ncbi.nlm.nih.gov/pubmed/29168435
http://dx.doi.org/10.1080/15476286.2017.1397262

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