Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions of the RNA-binding protein (RBP) TDP-43, and often the presence of a GGGGCC ex...

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Detalles Bibliográficos
Autores principales: Conlon, Erin G, Fagegaltier, Delphine, Agius, Phaedra, Davis-Porada, Julia, Gregory, James, Hubbard, Isabel, Kang, Kristy, Kim, Duyang, Phatnani, Hemali, Shneider, Neil A, Manley, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103746/
https://www.ncbi.nlm.nih.gov/pubmed/30003873
http://dx.doi.org/10.7554/eLife.37754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103746/
https://www.ncbi.nlm.nih.gov/pubmed/30003873
http://dx.doi.org/10.7554/eLife.37754

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