Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase

Cysteine dioxygenase (CDO) plays an essential role in sulfur metabolism by regulating homeostatic levels of cysteine. Human CDO contains a posttranslationally generated Cys93–Tyr157 crosslinked cofactor. Here, we investigated this Cys-Tyr crosslinking by incorporating unnatural tyrosines in place of...

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Detalles Bibliográficos
Autores principales: Li, Jiasong, Griffith, Wendell P., Davis, Ian, Shin, Inchul, Wang, Jiangyun, Li, Fahui, Wang, Yifan, Wherritt, Daniel J., Liu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103799/
https://www.ncbi.nlm.nih.gov/pubmed/29942080
http://dx.doi.org/10.1038/s41589-018-0085-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103799/
https://www.ncbi.nlm.nih.gov/pubmed/29942080
http://dx.doi.org/10.1038/s41589-018-0085-5

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