Facile target validation in an animal model with intracellularly expressed monobodies

Rapidly determining the biological effect of perturbing a site within a potential drug target could guide drug discovery efforts but it remains challenging. Here, we describe a facile target validation approach that exploits monobodies, small synthetic binding proteins that can be fully functionally...

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Detalles Bibliográficos
Autores principales: Gupta, Ankit, Xu, Jing, Lee, Shirley, Tsai, Steven T., Zhou, Bo, Kurosawa, Kohei, Werner, Michael S., Koide, Akiko, Ruthenburg, Alexander J., Dou, Yali, Koide, Shohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103845/
https://www.ncbi.nlm.nih.gov/pubmed/30013062
http://dx.doi.org/10.1038/s41589-018-0099-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103845/
https://www.ncbi.nlm.nih.gov/pubmed/30013062
http://dx.doi.org/10.1038/s41589-018-0099-z

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