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Facile target validation in an animal model with intracellularly expressed monobodies
Rapidly determining the biological effect of perturbing a site within a potential drug target could guide drug discovery efforts but it remains challenging. Here, we describe a facile target validation approach that exploits monobodies, small synthetic binding proteins that can be fully functionally...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103845/ https://www.ncbi.nlm.nih.gov/pubmed/30013062 http://dx.doi.org/10.1038/s41589-018-0099-z |