Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer’s disease (AD) and other tauopathies. MC1/Alz50 are currently the only antibodies targeting a disease-specific conformational modification of tau. Passive immunization experiments us...

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Detalles Bibliográficos
Autores principales: Vitale, Francesca, Giliberto, Luca, Ruiz, Santiago, Steslow, Kristen, Marambaud, Philippe, d’Abramo, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103963/
https://www.ncbi.nlm.nih.gov/pubmed/30134961
http://dx.doi.org/10.1186/s40478-018-0585-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103963/
https://www.ncbi.nlm.nih.gov/pubmed/30134961
http://dx.doi.org/10.1186/s40478-018-0585-2

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