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Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice
Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer’s disease (AD) and other tauopathies. MC1/Alz50 are currently the only antibodies targeting a disease-specific conformational modification of tau. Passive immunization experiments us...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103963/ https://www.ncbi.nlm.nih.gov/pubmed/30134961 http://dx.doi.org/10.1186/s40478-018-0585-2 |