Mutations causing low level antibiotic resistance ensure bacterial survival in antibiotic-treated hosts

In 474 genome sequenced Pseudomonas aeruginosa isolates from 34 cystic fibrosis (CF) patients, 40% of these harbor mutations in the mexZ gene encoding a negative regulator of the MexXY-OprM efflux pump associated with aminoglycoside and fluoroquinolone resistance. Surprisingly, resistance to aminogl...

Descripción completa

Detalles Bibliográficos
Autores principales: Frimodt-Møller, Jakob, Rossi, Elio, Haagensen, Janus Anders Juul, Falcone, Marilena, Molin, Søren, Johansen, Helle Krogh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104031/
https://www.ncbi.nlm.nih.gov/pubmed/30131514
http://dx.doi.org/10.1038/s41598-018-30972-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104031/
https://www.ncbi.nlm.nih.gov/pubmed/30131514
http://dx.doi.org/10.1038/s41598-018-30972-y

Ejemplares similares