Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp(3))–H bonds

Construction of C–C bonds via alkoxy radical-mediated remote C(sp(3))–H functionalization is largely unexplored, as it is a formidable challenge to directly generate alkoxy radicals from alcohols due to the high bond dissociation energy (BDE) of O–H bonds. Disclosed herein is a practical and elusive...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xinxin, Zhang, Hong, Tang, Nana, Wu, Zhen, Wang, Dongping, Ji, Meishan, Xu, Yan, Wang, Min, Zhu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104081/
https://www.ncbi.nlm.nih.gov/pubmed/30131495
http://dx.doi.org/10.1038/s41467-018-05522-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104081/
https://www.ncbi.nlm.nih.gov/pubmed/30131495
http://dx.doi.org/10.1038/s41467-018-05522-9

Ejemplares similares