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Deletion of p75(NTR) prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the neurotrophin receptor; p75(NTR) can overcome retinal isc...

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Detalles Bibliográficos
Autores principales: Elshaer, Sally L., El-Remessy, Azza B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104090/
https://www.ncbi.nlm.nih.gov/pubmed/30131506
http://dx.doi.org/10.1038/s41598-018-30029-0