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Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study
Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Experimental studies indicate that intermittent hypoxia (IH) mimicking OSA induces oxidative stress and inflamm...
Autores principales: | Farré, Núria, Otero, Jorge, Falcones, Bryan, Torres, Marta, Jorba, Ignasi, Gozal, David, Almendros, Isaac, Farré, Ramon, Navajas, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104184/ https://www.ncbi.nlm.nih.gov/pubmed/30158879 http://dx.doi.org/10.3389/fphys.2018.01143 |
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