Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

BACKGROUND: Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expression in prostate cancer patients. PSMA I&T, a theranostic tracer developed...

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Detalles Bibliográficos
Autores principales: Wirtz, Martina, Schmidt, Alexander, Schottelius, Margret, Robu, Stephanie, Günther, Thomas, Schwaiger, Markus, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104465/
https://www.ncbi.nlm.nih.gov/pubmed/30136051
http://dx.doi.org/10.1186/s13550-018-0440-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104465/
https://www.ncbi.nlm.nih.gov/pubmed/30136051
http://dx.doi.org/10.1186/s13550-018-0440-2

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