Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

A series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4...

Descripción completa

Detalles Bibliográficos
Autores principales: Quan Wang, Jie, Di Yang, Meng, Chen, Xing, Wang, Yang, Zeng Chen, Liu, Cheng, Xiu, Hua Liu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104605/
https://www.ncbi.nlm.nih.gov/pubmed/30132373
http://dx.doi.org/10.1080/14756366.2018.1466881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104605/
https://www.ncbi.nlm.nih.gov/pubmed/30132373
http://dx.doi.org/10.1080/14756366.2018.1466881

Ejemplares similares