Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

Drug discovery campaigns directly targeting the voltage-gated sodium channel NaV1.7, a highly prized target in chronic pain, have not yet been clinically successful. In a differentiated approach, we demonstrated allosteric control of trafficking and activity of NaV1.7 by prevention of SUMOylation of...

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Detalles Bibliográficos
Autores principales: François-Moutal, Liberty, Scott, David Donald, Perez-Miller, Samantha, Gokhale, Vijay, Khanna, May, Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104687/
https://www.ncbi.nlm.nih.gov/pubmed/30081699
http://dx.doi.org/10.1080/19336950.2018.1491244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104687/
https://www.ncbi.nlm.nih.gov/pubmed/30081699
http://dx.doi.org/10.1080/19336950.2018.1491244

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