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Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: Analysis of methylation, acetylation and ubiquitination sites in human proteins

Intrinsically disordered regions (IDRs) of proteins play significant biological functional roles despite lacking a well-defined 3D structure. For example, IDRs provide efficient housing for large numbers of post-translational modification (PTM) sites in eukaryotic proteins. Here, we study the distri...

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Detalles Bibliográficos
Autores principales: Narasumani, Mohanalakshmi, Harrison, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105011/
https://www.ncbi.nlm.nih.gov/pubmed/30096183
http://dx.doi.org/10.1371/journal.pcbi.1006349