An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer

PURPOSE: Phase Ib study evaluating the effect of apalutamide, at therapeutic exposure, on ventricular repolarization by applying time-matched pharmacokinetics and electrocardiography (ECG) in patients with castration-resistant prostate cancer. Safety of daily apalutamide was also assessed. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales: Belderbos, Bodine P. S. I., de Wit, Ronald, Chien, Caly, Mitselos, Anna, Hellemans, Peter, Jiao, James, Yu, Margaret K., Attard, Gerhardt, Bulat, Iurie, Edenfield, W. Jeffrey, Saad, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105166/
https://www.ncbi.nlm.nih.gov/pubmed/29974203
http://dx.doi.org/10.1007/s00280-018-3632-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105166/
https://www.ncbi.nlm.nih.gov/pubmed/29974203
http://dx.doi.org/10.1007/s00280-018-3632-6

Ejemplares similares