Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes where, upon reactivation by antigen, they rapidly pro...

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Detalles Bibliográficos
Autores principales: Moran, Imogen, Nguyen, Akira, Khoo, Weng Hua, Butt, Danyal, Bourne, Katherine, Young, Clara, Hermes, Jana R., Biro, Maté, Gracie, Gary, Ma, Cindy S., Munier, C. Mee Ling, Luciani, Fabio, Zaunders, John, Parker, Andrew, Kelleher, Anthony D., Tangye, Stuart G., Croucher, Peter I., Brink, Robert, Read, Mark N., Phan, Tri Giang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105623/
https://www.ncbi.nlm.nih.gov/pubmed/30135429
http://dx.doi.org/10.1038/s41467-018-05772-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105623/
https://www.ncbi.nlm.nih.gov/pubmed/30135429
http://dx.doi.org/10.1038/s41467-018-05772-7

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