Glycosylation Significantly Inhibits the Aggregation of Human Prion Protein and Decreases Its Cytotoxicity

Prion diseases are primarily caused by the misfolding of prion proteins in humans, cattle, sheep, and cervid species. The effects of glycosylation on prion protein (PrP) structure and function have not been thoroughly elucidated to date. In this study, we attempt to elucidate the effects of glycosyl...

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Detalles Bibliográficos
Autores principales: Yi, Chuan-Wei, Wang, Li-Qiang, Huang, Jun-Jie, Pan, Kai, Chen, Jie, Liang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105643/
https://www.ncbi.nlm.nih.gov/pubmed/30135544
http://dx.doi.org/10.1038/s41598-018-30770-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105643/
https://www.ncbi.nlm.nih.gov/pubmed/30135544
http://dx.doi.org/10.1038/s41598-018-30770-6

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