One-pot aminobenzylation of aldehydes with toluenes

Amines are fundamental motifs in bioactive natural products and pharmaceuticals. Using simple toluene derivatives, a one-pot aminobenzylation of aldehydes is introduced that provides rapid access to amines. Simply combining benzaldehydes, toluenes, NaN(SiMe(3))(2), and additive Cs(O(2)CCF(3)) (0.35...

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Detalles Bibliográficos
Autores principales: Wang, Zhiting, Zheng, Zhipeng, Xu, Xinyu, Mao, Jianyou, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105668/
https://www.ncbi.nlm.nih.gov/pubmed/30135427
http://dx.doi.org/10.1038/s41467-018-05638-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105668/
https://www.ncbi.nlm.nih.gov/pubmed/30135427
http://dx.doi.org/10.1038/s41467-018-05638-y

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