Bonsai Gelsolin Survives Heat Induced Denaturation by Forming β-Amyloids which Leach Out Functional Monomer

Here, we report that minimal functional gelsolin i.e. fragment 28–161 can display F-actin depolymerizing property even after heating the protein to 80 °C. Small angle X-ray scattering (SAXS) data analysis confirmed that under Ca(2+)-free conditions, 28–161 associates into monomer to dimer and tetram...

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Detalles Bibliográficos
Autores principales: Badmalia, Maulik D., Sharma, Pankaj, Yadav, Shiv Pratap Singh, Singh, Shikha, Khatri, Neeraj, Garg, Renu, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105678/
https://www.ncbi.nlm.nih.gov/pubmed/30135452
http://dx.doi.org/10.1038/s41598-018-30951-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105678/
https://www.ncbi.nlm.nih.gov/pubmed/30135452
http://dx.doi.org/10.1038/s41598-018-30951-3

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