JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. However, how this histone modifier affects in a cell type-dependent manner remains unclear. Here, we show that in contrast to its oncogenic effect in preleukemi...

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Detalles Bibliográficos
Autores principales: Yu, Shan-He, Zhu, Kang-Yong, Chen, Juan, Liu, Xiang-Zhen, Xu, Peng-Fei, Zhang, Wu, Yan, Li, Guo, He-Zhou, Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105679/
https://www.ncbi.nlm.nih.gov/pubmed/30135572
http://dx.doi.org/10.1038/s41467-018-05548-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105679/
https://www.ncbi.nlm.nih.gov/pubmed/30135572
http://dx.doi.org/10.1038/s41467-018-05548-z

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